Walsh Laboratory

Research Interests

• Role of adipocyte-derived factors in the development of cardiovascular disease.

Current Position

• 2007: Postdoctoral Fellow, Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine

Past Positions and Honors

• 1997–1998: Resident, Internal Medicine, Osaka University Hospital, Osaka, Japan.
• 1998-2000: Resident, Internal Medicine, Rinku General Medical Center, Japan.
• 2000-2001: Staff Doctor, Cardiovascular Medicine, National Hospital Organization Kure Medical Center, Hiroshima, Japan.
• 2001-2002: Staff Doctor, Cardiovascular Medicine, Osaka University Hospital, Osaka, Japan.
• 2006-2007: Staff Doctor, Internal Medicine, Rinku General Medical Center, Japan.

Education

• MD Medicine - Osaka University School of Medicine - 1997
• PhD Medicine - Osaka University Graduate School of Medicine - 2006

Publications

1. K. Ohashi, H. Iwatani, S. Kihara, Y. Nakagawa, N. Komura, K. Fujita, N. Maeda, M. Nishida, F. Katsube, I. Shimomura, T. Ito, T. Funahashi (2007). Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice. Arterioscler Thromb Vasc Biol. 27: 1910-17.

2. K. Ohashi, S. Kihara, N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, K. Maeda, R. Shibata, K. Walsh, T. Funahashi, I. Shimomura (2006). Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47: 1108-1116.

3. K.Ohashi, N. Ouchi, S. Kihara, T. Funahashi, T. Nakamura, S. Sumitsuji, T. Kawamoto, S. Matsumoto, H. Nagaretani, M. Kumada, Y. Okamoto, H. Nishizawa, K. Kishida, N. Maeda, H. Hiraoka, Y. Iwashima, K. Ishikawa, M. Ohishi, T. Katsuya, H. Rakugi, T. Ogihara, Y. Matsuzawa (2004). Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol. 43: 1195-1200.

4. K. Ohashi, T. Funahashi (2006). Mutations and polymorphisms in adiponectin gene. Nippon Rinsho . 28 Suppl. 3: 264-268.

5. A. Kurata, H. Nishizawa, S. Kihara, N. Maeda, M. Sonoda, T. Okada, K. Ohashi, T. Hibuse, K. Fujita, A. Yasui, A, Hiuge, M. Kumada, H. Kuriyama, I. Shimomura, T. Funahashi. Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. Kidney Int. In Press.

6. R.Shibata, N. Ouchi, M. Ito, S. Kihara, I. Shiojima, D.R. Pimentel, M. Kumada, K. Sato, S. Schiekofer, K. Ohashi , T. Funahashi, W.S. Colucci, K. Walsh (2004). Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat. Med. 10: 1384-1389.

7. Y. Iwashima, T. Katsuya, K. Ishikawa, N. Ouchi, M. Ohishi, K. Sugimoto, Y. Fu, M. Motone, K. Yamamoto, A. Matsuo, K. Ohashi, S. Kihara, T. Funahashi, H. Rakugi, Y. Matsuzawa, T. Ogihara (2004). Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 43: 1318-23.

8. M. Kumada, S. Kihara, N. Ouchi, H. Kobayashi, Y. Okamoto,K. Ohashi, K. Maeda, H. Nagaretani, K. Kishida, N. Maeda, A. Nagasawa, T. Funahashi, Y. Matsuzawa (2004). Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 109: 2046-49.

9. N. Ouchi, M. Ohishi, S. Kihara, T. Funahashi, T. Nakamura, H. Nagaretani, M. Kumada, K. Ohashi, Y. Okamoto, H. Nishizawa, K. Kishida, N. Maeda, A. Nagasawa, H. Kobayashi, H. Hiraoka, N. Komai, M. Kaibe, H. Rakugi, T. Ogihara, Y. Matsuzawa (2003). Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42: 231-4.

10. K. Kishida, H. Nagaretani, H. Kondo, H. Kobayashi, S. Tanaka, N. Maeda, A. Nagasawa, T. Hibuse,K. Ohashi , M. Kumada, H. Nishizawa, Y. Okamoto, N. Ouchi, K. Maeda, S. Kihara, T. Funahashi, Y. Matsuzawa (2003). Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochem Biophys Res Commun. 306: 286-92.

11. N. Sakai, Y. Uchida, K. Ohashi, T. Hibuse, Y. Saika, Y. Tomari, S. Kihara, H. Hiraoka, S. Ito, S. Yamashita, Y. Matsuzawa (2003). Measurement of fasting serum apoB-48 levels in normolipidemic and hyperlipidemic subjects by ELISA. J.Lipid Res. 44: 1256-62.

12. Y. Okamoto, S. Kihara, N. Ouchi, M. Nishida, Y. Arita, M. Kumada,K. Ohashi, N. Sakai, I. Shimomura, H. Kobayashi, N. Terasaka, T. Inaba, T. Funahashi, Y. Matsuzawa (2003). Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation107: 671-4.

13. Y.Okamoto, S. Kihara, N. Ouchi, M. Nishida, Y. Arita, M. Kumada, K. Ohashi, N. Sakai, I.Shimomura, H. Kobayashi, N. Terasaka, T. Inaba, T. Funahashi, Y. Matsuzawa (2002). Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106: 2767-2770.