Noriyuki Ouchi, MD, PhD

Noriyuki Ouchi, MD, PhD

Molecular Cardiology/CVI
Boston University School of Medicine
715 Albany Street, W611
Boston, Massachusetts  02118

Phone: (617) 414-2395
Fax: (617) 414-2391
Email: nouchi@bu.edu

Research Interests

  • Role of adipocyte-derived factors in the development of cardiovascular disease.
  • Molecular identification of novel factors of Akt signaling pathway.

Current Position

  • 2005: Assistant Professor, Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine

Past Positions and Honors

  • 1990-1991: Resident, Second Department of Internal Medicine, Osaka University Medical School, Japan
  • 1991-1994: Clinical Associate, Internal Medicine and Coronary Care Unit, Kawasaki Hospital, Kobe, Japan
  • 1994-2003: Fellow, Laboratory of Lipid and Circulation, Department of Internal Medicine and Molecular Science, Osaka University, Japan
  • 2000: Young Investigator Award, Japanese Endocrine Society
  • 2001: Young Investigator Award, Japanese Circulation Society
  • 2002: Young Investigator Award, Japanese Vascular Biology Organization
  • 2003-2005: Research Associate, Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine
  • 2006: American Heart Association Scientist Development Award

Education

  • MD Medicine - Osaka University Medical School - 1990
  • PhD Cardiology - Osaka University - 2001

Publications

  1. Y. Takemura, N. Ouchi, R. Shibata, T. Aprahamian, MT. Kirber, RS. Summer, S. Kihara, K. Walsh (2006). Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest In press.

  2. TA. Hopkins, N. Ouchi, R. Shibata, K. Walsh (2006). Adiponectin actions in the cardiovascular system. Cardiovasc Res [Epub ahead of print]

  3. N. Ouchi, R. Shibata, K. Walsh (2006). Targeting adiponectin for cardioprotection. Expert Opin Ther Targets 10: 573-581.

  4. N. Ouchi, R. Shibata, K. Walsh (2006). Cardioprotection by adiponectin. Trends Cardiovasc Med 16: 141-146.

  5. K. Ohashi, S. Kihara, N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, K. Maeda, R. Shibata, K. Walsh, T. Funahashi, I. Shimomura (2006). Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension47: 1108-1116.

  6. G. Galasso, S. Schiekofe, K. Sato, R. Shibata, DE. Handy, N. Ouchi, JA. Leopold, J. Loscalzo, K. Walsh (2005). Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res 98: 254-261.

  7. K. Ohashi, S. Kihara,N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, K. Maeda, R. Shibata, K. Walsh K, T. Funahashi, I. Shimomura (2006). Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47: 1108-1116.

  8. R. Shibata, K. Sato, D.R. Pimentel, Y. Takemura, S. Kihara, K. Ohashi, T. Funahashi, N. Ouchi, K. Walsh (2005). Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2- dependent mechanisms. Nat. Med. 10: 1096-1103.

  9. E. Ackah, J. Yu, S. Zoellner, Y. Iwakiri, C. Skurk, R. Shibata, N. Ouchi, R.M. Easton, G. Galasso, M.J. Birnbaum, K. Walsh and W.C. Sessa (2005). Akt1/Protein Kinase Bα is critical for ischemic and vascular endothelial growth factor mediated angiogenesis. J. Clin. Invest. 115: 2119-2127.

  10. Y. Liao, S. Takashima, N. Maeda, N. Ouchi, K. Komamura, I. Shimomura, M. Hori, Y. Matsuzawa, T. Funahashi, M. Kitakaze (2005). Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc. Res. 67: 705-713.

  11. N. Ouchi, R. Shibata and K. Walsh (2005). AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ. Res. 96: 838-846.

  12. Y. Iwashima, T. Katsuya, K. Ishikawa, I. Kida, M. Ohishi, T. Horio, N. Ouchi, K. Ohashi, S. Kihara, T. Funahashi, H. Rakugi, T. Ogihara (2005). Association of hypoadiponectinemia with smoking habit in men. Hypertension 45: 1094-1100.

  13. R. Shibata, N. Ouchi, M. Ito, S. Kihara, I. Shiojima, D.R. Pimentel, M. Kumada, K. Sato, S. Schiekofer, K. Ohashi, T. Funahashi, W.S. Colucci, K. Walsh (2004). Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat. Med. 10: 1384-1389.

  14. R. Shibata, N. Ouchi, S. Kihara, K. Sato, T. Funahashi and K. Walsh (2004). Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. J. Biol. Chem. 279: 28670-28674.

  15. H. Kobayashi, N. Ouchi, S. Kihara, K. Walsh, M. Kumada, Y. Abe, T. Funahashi and Y. Matsuzawa (2004). Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ. Res. 94: e27-e31.

  16. N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, T. Inoue, T. Funahashi and K. Walsh (2004). Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279: 1304-1309.

  17. A. Sierksma, H. Patel, N. Ouchi, S. Kihara, T. Funahashi, R.J. Heine, D.E. Grobbee, C. Kluft, H.F. Hendriks (2004). Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care 27: 184-189.

  18. M. Sata, A. Takahashi, K. Tanaka, M. Washida, N. Ishizaka, J. Ako, M. Yoshizumi, Y. Ouchi, T. Taniguchi, Y. Hirata, M. Yokoyama, R. Nagai and K. Walsh (2002). Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway. Arterioscler. Thromb. Vasc. Biol. 22: 1305-1309.

  19. N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa and K. Walsh (2003). Obesity, adiponectin and vascular inflammatory disease. Curr. Opin. Lipid. 14: 561-566.

  20. N. Ouchi, M. Ohishi, S. Kihara, T. Funahashi, T. Nakamura, H. Nagaretani, M. Kumada, K. Ohashi, Y. Okamoto, H. Nishizawa, K. Kishida, N. Maeda, A. Nagasawa, H. Kobayashi, H. Hiraoka, N. Komai, M. Kaibe, H. Rakugi, T. Ogihara, Y. Matsuzawa (2003). Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42: 231-234.

  21. K. Kishida, H. Nagaretani, H. Kondo, H. Kobayashi, S. Tanaka, N. Maeda, A. Nagasawa, T. Hibuse, K. Ohashi, M. Kumada, H. Nishizawa, Y. Okamoto, N. Ouchi, K. Maeda, S. Kihara, T. Funahashi, Y. Matsuzawa (2003). Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochem. Biophys. Res. Commun. 306: 286-292.

  22. S. Kojima, T. Funahashi, T. Sakamoto, S. Miyamoto, H. Soejima, J. Hokamaki, I. Kajiwara, S. Sugiyama, M. Yoshimura, K. Fujimoto, Y. Miyao, H. Suefuji, A. Kitagawa, N. Ouchi, S. Kihara, Y. Matsuzawa, H. Ogawa (2003). The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction. Heart 89: 667.

  23. C. Zoccali, F. Mallamaci, V. Panuccio, G. Tripepi, S. Cutrupi, S. Parlongo, F. Catalano, S. Tanaka, N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa (2003). Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors. Kidney Int. Suppl: S98-S102.

  24. Y. Saika, N. Sakai, M. Takahashi, T. Maruyama, S. Kihara, N. Ouchi, M. Ishigami, H. Hiraoka, T. Nakamura, S. Yamashita, Y. Matsuzawa (2003). Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis. Eur. J. Clin. Invest. 33: 216-222.

  25. N. Ouchi, S. Kihara, T. Funahashi, T. Nakamura, M. Nishida, M. Kumada, Y. Okamoto, K. Ohashi, H. Nagaretani, K. Kishida, H. Nishizawa, N. Maeda, H. Kobayashi, H. Hiroka, Y. Matsuzawa (2003). Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107: 671-674.

  26. M. Kumada, S. Kihara, S. Sumitsuji, T. Kawamoto, S. Matsumoto, N. Ouchi, Y. Arita, Y. Okamoto, I. Shimomura, H. Hiraoka, T. Nakamura, T. Funahashi, Matsuzawa Y; Osaka CAD Study Group (2003). Coronary artery disease. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler. Thromb. Vasc. Biol. 23: 85-89.

  27. F. Mallamaci, C. Zoccali, F. Cuzzola, G. Tripepi, S. Cutrupi, S. Parlongo, S. Tanaka, N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa (2003). Adiponectin in essential hypertension. J. Nephrol. 15: 507-511.

  28. Y. Okamoto, S. Kihara, N. Ouchi, M. Nishida, Y. Arita, M. Kumada, K. Ohashi, N. Sakai, I. Shimomura, H. Kobayashi, N. Terasaka, T. Inaba, T. Funahashi, Y. Matsuzawa (2002). Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106: 2767-2770.

  29. M. Matsuda, I. Shimomura, M. Sata, Y. Arita, M. Nishida, N. Maeda, M. Kumada, Y. Okamoto, H. Nagaretani, H. Nishizawa, K. Kishida, R. Komuro, N. Ouchi, S. Kihara, R. Nagai, T. Funahashi, Y. Matsuzawa (2002). Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J. Biol. Chem. 277: 37487-37491.

  30. H. Kondo, I. Shimomura, Y. Matsukawa, M. Kumada, M. Takahashi, M. Matsuda, N. Ouchi, S. Kihara, T. Kawamoto, S. Sumitsuji, T. Funahashi, Y. Matsuzawa (2002). Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 51: 2325-2328.

  31. Y. Arita, S. Kihara, N. Ouchi, K. Maeda, H. Kuriyama, Y. Okamoto, M. Kumada, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, I. Shimomura, M. Muraguchi, Y. Ohmoto, T. Funahashi, Y. Matsuzawa (2002). Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105: 2893-2898.

  32. N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, H. Nagaretani, N. Furuyama, H. Kondo, M. Takahashi, Y. Arita, R. Komuro, N. Ouchi, S. Kihara, Y. Tochino, K. Okutomi, M. Horie, S. Takeda, T. Aoyama, T. Funahashi, Y. Matsuzawa (2002). Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med. 8: 731-737.

  33. C. Zoccali, F. Mallamaci, G. Tripepi, F.A. Benedetto, S. Cutrupi, S. Parlongo, L.S Malatino, G. Bonanno, G. Seminara, F. Rapisarda, P. Fatuzzo, M. Buemi, G. Nicocia, S. Tanaka, N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa (2002). Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J. Am. Soc. Nephrol. 13: 134-141.

  34. T. Nakamura, T. Funahashi, S. Yamashita, M. Nishida, Y. Nishida, M. Takahashi, K. Hotta, H. Kuriyama, S. Kihara, N. Ouchi, T. Nishimura, B.I. Kishino, K. Ishikawa, T. Kawamoto, K. Tokunaga, C. Nakagawa, I. Mineo, F. Watanabe, S. Tarui, Y. Matsuzawa (2001). Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial. Diabetes Res. Clin. Pract. 54: 181-190.

  35. K. Kishida, I. Shimomura, H. Nishizawa, N. Maeda, H. Kuriyama, H. Kondo, M. Matsuda, H. Nagaretani, N. Ouchi, K. Hotta, S. Kihara, T. Kadowaki, T. Funahashi, Y. Matsuzawa (2001). Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 276: 48572-48579.

  36. N. Maeda, M. Takahashi, T. Funahashi, S. Kihara, H. Nishizawa, K. Kishida, H. Nagaretani, M. Matsuda, R. Komuro, N. Ouchi, H. Kuriyama, K. Hotta, T. Nakamura, I. Shimomura, Y. Matsuzawa (2001). PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50: 2094-2099.

  37. K. Kishida, I. Shimomura, H. Kondo, H. Kuriyama, Y. Makino, H. Nishizawa, N. Maeda, M. Matsuda, N. Ouchi, S. Kihara, Y. Kurachi, T. Funahashi, Y. Matsuzawa (2001). Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel. J. Biol. Chem. 276: 36251-36260.

  38. M. Takahashi, H. Nagaretani, T. Funahashi, H. Nishizawa, N. Maeda, K. Kishida, H. Kuriyama, I. Shimomura, K. Maeda, K. Hotta, N. Ouchi, S. Kihara, T. Nakamura, S. Yamashita, Y. Matsuzawa (2001). The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease. Obes. Res. 9: 388-393.

  39. N. Ouchi, S. Kihara, Y. Arita, M. Nishida, A. Matsuyama, Y. Okamoto, M. Ishigami, H. Kuriyama, K. Kishida, H. Nishizawa, K. Hotta, M. Muraguchi, Y. Ohmoto, S. Yamashita, T. Funahashi, Y. Matsuzawa (2001). Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103: 1057-1063.

  40. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, K. Maeda, H. Kuriyama, K. Hotta, M. Nishida, M. Takahashi, M. Muraguchi, Y. Ohmoto, T. Nakamura, S. Yamashita, T. Funahashi, Y. Matsuzawa (2000). Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation 102: 1296-1301.

  41. T. Yokota, K. Oritani, I. Takahashi, J. Ishikawa, A. Matsuyama, N. Ouchi, S. Kihara, T. Funahashi, A.J. Tenner, Y. Tomiyama, Y. Matsuzawa (2000). Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96: 1723-1732.

  42. K. Hotta, T. Funahashi, Y. Arita, M. Takahashi, M. Matsuda, Y. Okamoto, H. Iwahashi, H. Kuriyama, N. Ouchi, K. Maeda, M. Nishida, S. Kihara, N. Sakai, T. Nakajima, K. Hasegawa, M. Muraguchi, Y. Ohmoto, T. Nakamura, S. Yamashita, T. Hanafusa, Y. Matsuzawa (2000). Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 20: 1595-1599.

  43. R. Komuro, S. Yamashita, S. Sumitsuji, K. Hirano, T. Maruyama, M. Nishida, F. Matsuura, A. Matsuyama, T. Sugimoto, N. Ouchi, N. Sakai, T. Nakamura, T. Funahashi, Y. Matsuzawa (2000). Tangier disease with continuous massive and longitudinal diffuse calcification in the coronary arteries: demonstration by the sagittal images of intravascular ultrasonography. Circulation 101: 2446-2448.

  44. M. Nishida, J. Miyagawa, S. Yamashita, S. Higashiyama, A. Nakata, N. Ouchi, R. Tamura, K. Yamamori, S. Kihara, N. Taniguchi, Y. Matsuzawa (2000). Localization of CD9, an enhancer protein for proheparin-binding epidermal growth factor-like growth factor, in human atherosclerotic plaques: possible involvement of juxtacrine growth mechanism on smooth muscle cell proliferation. Arterioscler. Thromb. Vasc. Biol. 20: 1236-1243

  45. K. Kishida, H. Kuriyama, T. Funahashi, I. Shimomura, S. Kihara, N. Ouchi, M. Nishida, H. Nishizawa, M. Matsuda, M. Takahashi, K. Hotta, T. Nakamura, S. Yamashita, Y. Tochino, Y. Matsuzawa (2000). Aquaporin adipose, a putative glycerol channel in adipocytes. J. Biol. Chem. 275: 20896-20902.

  46. Y. Okamoto, Y. Arita, M. Nishida, M. Muraguchi, N. Ouchi, M. Takahashi, T. Igura, Y. Inui, S. Kihara, T. Nakamura, S. Yamashita, J. Miyagawa, T. Funahashi, Y. Matsuzawa (2000). An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm. Metab. Res. 32: 47-50.

  47. N. Ouchi, S. Kihara, Y. Arita, K. Maeda, H. Kuriyama, Y. Okamoto, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, S. Yamashita, T. Funahashi, Y. Matsuzawa (1999). Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: 2473-2476.

  48. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, J. Miyagawa, K. Hotta, I. Shimomura, T. Nakamura, K. Miyaoka, H. Kuriyama, M. Nishida, S. Yamashita, K. Okubo, K. Matsubara, M. Muraguchi, Y. Ohmoto, T. Funahashi, Y. Matsuzawa (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257: 79-83.

  49. E. Shinohara, S. Kihara, N. Ouchi, T. Funahashi, T. Nakamura, S. Yamashita, Kameda-K. Takemura, Y. Matsuzawa (1998). Troglitazone suppresses intimal formation following balloon injury in insulin-resistant Zucker fatty rats. Atherosclerosis 136: 275-279.

  50. S. Kihara, N. Ouchi, T. Funahashi, E. Shinohara, R. Tamura, S. Yamashita, Y. Matsuzawa (1998). Troglitazone enhances glucose uptake and inhibits mitogen-activated protein kinase in human aortic smooth muscle cells. Atherosclerosis 136: 163-168.

  51. N. Ouchi, S. Kihara, S. Yamashita, S. Higashiyama, T. Nakagawa, I. Shimomura, T. Funahashi, Kameda-K. Takemura, S. Kawata, N. Taniguchi, Y. Matsuzawa (1997). Role of membrane-anchored heparin-binding epidermal growth factor-like growth factor and CD9 on macrophages. J. Biochem. 328: 923-928.

  52. N. Maeda, H. Hiraoka, T. Nakamura, F. Matsuura, N. Ouchi, A. Nakata, H. Kobayashi, S. Yamashita, Kameda-K. Takemura, Y. Matsuzawa (1997). Acetylcholine-induced coronary microvascular vasospasm in a patient with angina pectoris and normal coronary angiogram--a case report. Angiology 48: 995-999.

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Last modified: March 09, 2007 17:37:41 -0500