Walsh Laboratory

Research Interests

• Myocardial Protection.

Current Position

• 2006: Postdoctoral Fellow, Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine

Past Positions and Honors

• 1995-1996: Resident, Department of Internal Medicine, Osaka University Hospital, Suita, Japan
• 1996-1998: Resident, Deparmtent of Internal Medicine, Kinki Chuo Hospital, Itami, Japan
• 1998-1999: Resident, Department of Cardiology, Osaka Prefectural Habikino Hospital, Japan
• 1999-2000: Staff Doctor, Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital, Japan
• 2000-2004: Graduate Student, Department of Molecular Medicine, Osaka School of Medicine
• 2004-2005: Staff Doctor, Osaka Second Police Hospital, Japan

Education

• MD Medicine - Osaka University School of Medicine - 1995
• PhD Medicine - Osaka University School of Medicine - 2005

Publications

1. T. Mohri, Y. Fujio, Y. Maeda, T. Ito, T. Iwakura, Y. Oshima (2006). Leukemia Inhibitory Factor Induces Endothelial Differentiation in Cardiac Stem Cells. J Biol Chem. 281: 6442-6447

2. T. Kuroda, T. Hirota, H. Masaki, M. Sugiyama, Y. Oshima , Y. Terai, A. Ito, K. Yamauchi-Takihara (2005). Sildenafil as adjunct therapy to high-dose epoprostenol in a patient with pulmonary veno-occlusive disease. Heart Lung Circ. 2: 139-142

3. M. Mazuki, M. Izumi, Y. Oshima T. Nakaoka, Y. Kuroda, R. Kimura, S. Sugiyama, K. Terai, K., M. Kitakaze, K. Yamauchi-Takihara, I. Kawase, I., H. Hirota (2005). Smad1 protects cardiomyocytes from ischemia-reperfusion injury. Circulation 111: 2752-2759

4. Y. Oshima, Y. Fujio, T. Nakanishi, N. Itoh, Y. Yamamoto, S. Negoro, K. Tanaka, T. Kishimoto, I. Kawase, J. Azuma (2005). STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart. Cardiovasc. Res. 65: 428-435

5. H. Hirota, M. Izumi, T. Hamaguchi, S. Sugiyama, E. Murakami, K. Kunisada, Y. Fujio, Y. Oshima , Y. Nakaoka, K. Yamauchi-Takihara (2004). Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels 19: 237-241

6. Y. Fujio, T. Matsuda, Y. Oshima, M. Maeda, T. Mohri, T. Ito, T. Takatani, M. Hirata, Y. Nakaoka, R. Kimura, T. Kishimoto, J. Azuma (2004). Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. FEBS Lett. 27:573: 202-206

7. S. Sugiyama, H. Hirota, M. Yoshida, Y. Takemura, Y. Nakaoka, Y. Oshima, K. Terai, M. Izumi, Y. Fujio, S. Hasegawa, T. Mano, Y. Nakatsuchi, M. Hori, K. Yamauchi-Takihara, I. Kawase (2004). Novel Insertional Mutation in the Bone Morphogenetic Protein Receptor Type II Associated With Sporadic Primary Pulmonary Hypertension. Circ J. 68: 592-594

8. M. Masaki, T. Kuroda, N. Hosen, H. Hirota, K. Terai,Y. Oshima, Y. Nakaoka, S. Sugiyama, R. Kimura, S. Yoshihara, M. Kawakami, N. Iizuka, Y. Tomita, H. Ogawa, I. Kawase, K. Yamauchi-Takihara (2004) Solitary right ventricle metastasis by renal cell carcinoma.J Am Soc Echocardiogr. 17: 397-398

9. Y. Nakaoka, K. Nishida, Y. Fujio, M. Izumi, K. Terai,Y. Oshima, S. Sugiyama, S. Matsuda, S. Koyasu, K. Yamauchi-Takihara, T. Hirano, I. Kawase, H. Hirota (2003). Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. Circ Res. 93: 221-229

10. H. Nagai, Y. Oshima, H. Hirota, M. Izumi, S. Sugiyama, Y. Nakaoka, K. Terai, S. Hasegawa, H. Tateyama, M. Kikui, K. Yamauchi-Takihara, I. Kawase (2003). Specific cardiomyopathy caused by multisystemic lipid storage in Jordans' anomaly. Intern Med. 42: 587-590

11. K. Kunisada, E. Tone, S. Negoro, Y. Nakaoka,Y. Oshima, T. Osugi, M. Funamoto, M. Izumi, Y. Fujio, H. Hirota, K. Yamauchi-Takihara (2002). Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation. Cardiovasc Res. 53: 936-943

12. Y. Oshima, H. Hirota, H. Nagai, M. Izumi, Y. Nakaoka, T. Osugi, Y. Fujio, H. Tateyama, M. Kikui, K. Yamauchi-Takihara, I. Kawase (2002). Specific cardiomyopathy caused by multisystemic lipid storage in Jordan's anomaly. Circulation 106: 280-281

13. Y. Oshima, Y. Fujio, M. Funamoto, S. Negoro, M. Izumi, Y. Nakaoka, H. Hirota, K. Yamauchi-Takihara, I. Kawase (2002). Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway. FEBS Lett. 524: 123-126

14. Y. Nakaoka, K. Iwahori, K. Kunisada, Y. Fujio, M. Izumi, T. Osugi,Y. Oshima, H. Hirota, K. Yamauchi-Takihara (2002). A case of hypereosinophilic syndrome presenting mid-ventricular obstruction.Heart Vessels 16: 121-124

15. T. Osugi,Y. Oshima, Y. Fujio, M. Funamoto, A. Yamashita, S. Negoro, K. Kunisada, M. Izumi, Y. Nakaoka, H. Hirota, M. Okabe, K. Yamauchi-Takihara, I. Kawase, T. Kishimoto (2002). J Biol Chem. 277: 6676-6681

16. S. Negoro, K. Kunisada, Y. Fujio, M. Funamoto, M.I. Darville, D.L. Eizirik, T. Osugi, M. Izumi,Y. Oshima, Y. Nakaoka, H. Hirota, T. Kishimoto, K. Yamauchi-Takihara (2001). Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.Circulation 104: 979-981