Publications

Contents

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  1. T. Aprahamian, Y. Takemura, D. Goukassian, K. Walsh (2008). Aging is associated with diminished apoptotic cell clearance in vivo. Clin. Exp. Immunol. In press

  2. Song Y, Coleman L, Shi J, Beppu H, Sato K, Walsh K (2008). Inflamation, Endothelial Injury, and Persistent Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice. Am J Physiol Heart Circ Physiol.

  3. X. Hou, S. Xu, K.A. Maitland-Toolan, K. Sato, B. Jiang, Y. Ido, F. Lan, K. Walsh, M. Wierzbicki, T.J. Verbeuren, R.A. Cohen, M. Zang (2008). SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J. Biol. Chem.

  4. S. Schiekofer, K. Belisle, G. Galasso, J. Schneider, T. Burster, G. Schmitz, B.O. Boehm, K. Walsh (2008). Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells. Angiogenesis.

  5. N. Ouchi, K. Walsh (2008). A novel role for adiponectin in the regulation of inflammation. Arterioscler. Thromb. Vasc. Biol. 28 :1219-1221.

  6. Y. Oshima, N. Ouchi, K. Sato, Y. Izumiya, D.R. Pimentel, K. Walsh (2008). Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation 117 :3099-3108.

  7. R. Shibata, Y. Numaguchi, K. Matsushita, T. Sone, R. Kubota, T. Ohashi, M. Ishii, S. Kihara, K. Walsh, N. Ouchi, T. Murohara (2008). Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction. Am. J. Cardio. 101 :1712-1715.

  8. R. Summer, F.F. Little, N. Ouchi, Y. Takemura, T. Aprahamian, D. Dwyer, K. Fitzsimmons, B. Suki, H. Parameswaran, A. Fine, K. Walsh (2008). Alveolar macrophage activation and an emphysema-like phenotype in adiponectin deficient mice. Cell. Mol. Physiol. 294 :L1035-L1042. Accompanied by editorial

  9. R. Shibata, C. Skurk, N. Ouchi, G. Galasso, K. Kondo, T. Ohashi, M. Shimano, S. Kihara, T. Murohara, K. Walsh (2008). Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett. 582 :1607-1612.

  10. M. Mogi, K. Walsh, M. Iwai, M. Horiuchi (2008). Akt-FOXO3a signaling affects human endothelial progenitor cell differentiation. Hypertens. Res. 31 :153-159.

  11. Y. Ikeda, K. Ohashi, R. Shibata, D.R. Pimentel, S. Kihara, N. Ouchi, K. Walsh (2008). Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes. FEBS Lett. 582 :1147-1150.

  12. H.Y. Lee, H.J. You, J.Y. Won, S.W. Youn, H.J. Cho, K.W. Park, W.Y. Park, J.S. Seo, Y.B. Park, K. Walsh, B.H. Oh, H.S. Kim (2008). ). Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. Arterioscler. Thromb. Vasc. Biol. 28 :302-308.

  13. H.Y. Lee, S.W. Youn, J.Y. Kim, K.W. Park, C.I. Hwang, W.Y. Park, B.H. Oh, Y.B. Park, K. Walsh, J.S. Seo, H.S. Kim (2008). FOXO3a turns the tumor necrosis factor receptor signaling towards apoptosis through reciprocal regulation of c-Jun N-terminal kinase and NF-kB. Arterioscler. Thromb. Vasc. Biol. 28 :112-120.

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  14. Y. Izumiya, T. Hopkins, C. Morris, K. Sato, L. Zeng, J. Viereck, JA. Hamilton, N. Ouchi, NK. LeBrasseur, K. Walsh (2007). Fast/glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. In press.

  15. S. Rao, IB. Lobov, JE. Vallance, K. Tsujikawa, I. Shiojima, S. Akunuru, K. Walsh, LE. Benjamin, RA. Lang (2007). Obligatory participation of macrophages in an Angiopoietin 2-mediated cell death switch. Development. 134 :4449-4458.

  16. Q. Zhou, J. Du, Z. Hu, K. Walsh, XH. Wang (2007). Evidence for adipose-muscle crosstalk: opposing regulation of muscle proteolysis by adiponectin and fatty acids. Endocrinology [Epub ahead of print].

  17. TL. Phung, G. Eyiah-Mensah, RK. O’Donnell, R. Bieniek, S. Shechter, K. Walsh, C. Kuperwasser, LE. Benjamin (2007). Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res. 67: 5070-5075.

  18. R. Shibata, Y. Izumiya, K. Sato, K. Papanicolaou, S. Kihara, WS. Colucci, F. Sam, N. Ouchi, K. Walsh (2007). Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J Mol Cell Cardiol. 42: 1065-1074.

  19. M. Chorny, B. Polyak, IS. Alferiev, K. Walsh, G. Friedman, R.J. Levy (2007). Magnetically driven plasmid DNA delivery with biodegradable polymeric nanoparticles. FASEB. J.21: 2510-2519.

  20. R. Shibata, K. Sato, M. Kumada, Y. Izumiya, M.Sonoda, S. Kihara, N. Ouchi, K. Walsh (2007). Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Cardiovasc. Res.3 471-479.

  21. HY. Lee, JW. Chung, SW. Youn, JY. Kim, KW. Park, BK. Koo, BH. Oh, YN. Park, B. Chaqour, K. Walsh, HS. Kim (2007).The forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res.100 302-304.

  22. B. Fisslthaler, I. Fleming, B. Keseru, K. Walsh, R. Busse (2007). Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme a reductase in endothelial cells via the AMP-activated protein kinase and FoxO1. Circ Res. 100: e12-e21.

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  23. Y. Takemura, N. Ouchi, R. Shibata, T. Aprahamian, MT. Kirber, RS. Summer, S. Kihara, K. Walsh (2006). Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 117: 375-386.

  24. K. Ohashi, S. Kihara,N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, K. Maeda, R. Shibata, K. Walsh, T. Funahashi, I. Shimomura (2006). Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension47: 1108-1116.

  25. G. Galasso, S. Schiekofe, K. Sato, R. Shibata, DE. Handy,N. Ouchi, JA. Leopold, J. Loscalzo, K. Walsh (2005). Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res 98: 254-261.

  26. Y. Izumiya, I. Shiojima, K. Sato, D.B. Wilson, W.S Celluci, and K. Walsh (2006). Vacsular Endothelial Growth Factor Blockade Promotes the Transition FromCompensatory Cardiac Hyppertrophy to Failure in Response to Pressure Overload. Hypertension 47:887-893

  27. S. Schiekofer, G. Galasso, M. Andrassy, T. Aprahamian, J. Schneider, and E. Rocnik (2006). Glucose control with insulin results in reduction of NF-kappaB-binding activity in mononuclear blood cells of patients with recently manifested type 1 diabetes. Diabetes Obes Metab. 8(5):473-482.

  28. T. Aprahamian, R. Bonegio, J. Rizzo, H. Perlman, D.J. Lefer, I.R. Rifkin, and K. Walsh (2006). Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J. Immunology 177(5):3028-3034.

  29. C.E. Moussa, Q. Fu, P. Kumar, A. Shtifman, J.R. Lopez, P.D. Allen, F. LaFerla, D. Weingberg, J. Margrane, T. Aprahamian, K. Walsh, K.M. Rosen, and H.W. Querforth (2006). Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB.J 20(12):2165-2167.

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  30. R. Shibata, K. Sato, D.R. Pimentel, Y. Takemura, S. Kihara, K. Ohashi, T. Funahashi, N. Ouchi, K. Walsh (2005). Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2- dependent mechanisms. Nat. Med. 11: 1096-1103.

  31. C.E. Silcox, R.C. Smith, R. King, N. McDannold, P. Bromley, K. Walsh and K. Hynynen (2005). MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate. Ultrasound. Med. Biol. 31: 965-970.

  32. E. Ackah, J. Yu, S. Zoellner, Y. Iwakiri, C. Skurk, R. Shibata, N. Ouchi, R.M. Easton, G. Galasso, M.J. Birnbaum, K. Walsh and W.C. Sessa (2005).Akt1/Protein Kinase Bα is critical for ischemic and vascular endothelial growth factor mediated angiogenesis. J. Clin. Invest. 115: 2119-2127.

  33. I. Shiojima, K. Sato, Y. Izumiya, S. Schiekofer, M. Ito, R. Liao, W.S. Colucci and K. Walsh (2005). Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115: 2108-2118.

  34. S. Schiekofer, G. Galasso, K. Sato, B.J. Kraus and K. Walsh (2005). Impaired revascularization in a mouse model of type 2 diabetes is associated with dysregulation of a complex angiogenic-regulatory network. Arterioscler. Thromb. Vasc. Biol. 25: 1603-1609. (data)

  35. K.W. Park, D.H. Kim, H.J. You, J.J. Sir, S.I. Jeon, S.W. Youn, H.M. Yang, C. Skurk, Y.B. Park, K. Walsh and H.S. Kim (2005). Activated forkhead transcription factor inhibits neointimal hyperplasia after angioplasty through induction of p27. Arterioscler. Thromb. Vasc. Biol. 25: 742-747.

  36. C. Skurk, Y. Izumiya, H. Maatz, P. Razeghi, I. Shiojima, M. Sandri, K. Sato, L. Zeng, S. Schiekofer, D. Pimentel, S. Lecker, H. Taegtmeyer, A.L. Goldberg and K. Walsh (2005). The FOXO3a transcription factor regulates cardiac myocyte size downstream of Akt signaling. J. Biol. Chem. 280: 20814-20823.

  37. C. Skurk, H. Maatz, E. Rocnik, A. Bialik, T. Force and K. Walsh (2005). Glycogen-synthase kinase3β/β-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells. Circ. Res. 96: 308-318.

  38. N. Ouchi, R. Shibata and K. Walsh (2005). AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ. Res. 96: 838-846.

  39. H.S. Kim, C. Skurk, H. Maatz, I. Shiojima, Y. Ivashchenko, S.W. Yoon, Y.B. Park and K. Walsh (2005) Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression. FASEB J. 19: 1042-1044. (data)

  40. Y. Taniyama, M. Ito, K. Sato, C. Kuester, K. Veit, R. Liao, W.S. Colucci, Y. Ivashchenko, K. Walsh and I. Shiojima (2005). Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. J. Mol. Cell. Cardiol. 38: 375-385.

  41. J.F. Sun, T. Phung, I. Shiojima, T. Felske, J.N. Upalakalin, D. Feng, T. Kornaga, T. Dor, A.M. Dvorak, K. Walsh, L.E. Benjamin (2005). Microvascular patterning is controlled by fine-tuning the Akt signal. Proc. Natl. Acad. Sci. USA 102: 128-133.

  42. S.P. Jones, J.J.M. Greer, P.D. Ware, J. Yang, K. Walsh and D.J. Lefer (2005). Deficiency of iNOS does not attenuate severe congestive heart failure in mice. Am. J. Physiol. Heart Circ. Physiol. 288: H365-H370.

  43. R. Shibata, N. Ouchi, M. Ito, S. Kihara, I. Shiojima, D.R. Pimentel, M. Kumada, K. Sato, S. Schiekofer, K. Ohashi, T. Funahashi, W.S. Colucci, K. Walsh (2004). Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat. Med. 10: 1384-1389.

  44. J.H. Choi, J. Hur, C.H. Yoon, J.H. Kim, C.S. Lee, S.W. Youn, I.Y. Oh, C. Skurk, T. Murohara, Y.B. Park, K. Walsh, H-S. Kim (2004). Augmentation of therapeutic angiogenesis using genetically-modified human endothelial progenitor cells with altered glycogen synthase kinase-3beta activity. J. Biol. Chem. 279: 49430-49438.

  45. M. Zang, A. Zuccullo, X. Hou, D. Nagata, K. Walsh, H. Herscovitz , P. Brecher , N.B. Ruderman, R.A. Cohen (2004). AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J. Biol. Chem. 279: 47898-47905.

  46. J. Yang, K. Sato, T Aprahamian, N.J. Brown, J. Hutcheson, A. Bialik, H. Perlman and K. Walsh (2004). Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 24: 1466-1473.

  47. R. Shibata, N. Ouchi, S. Kihara, K. Sato, T. Funahashi and K. Walsh (2004). Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. J. Biol. Chem. 279: 28670-28674.

  48. H.-M. Yang, H.-S. Kim, K.-W. Park, H.-J. You, Soo-In Jeon, BA, Seock-Won Youn, MS, Byung-Hee Oh, MD, Myoung-Mook Lee, MD, Young-Bae Park and K. Walsh (2004). Celecoxib, a cyclooxygenase(COX)-2 inhibitor, reduces neointimal hyperplasia through inhibition of Akt pathway. Circulation 110: 301-308.

  49. M. Sandri, C. Sandri, A. Gilbert, C. Skurk, E. Calabria, A. Picard, K. Walsh, S. Schiaffino, S.H. Lecker, A.L. Goldberg (2004). Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 117: 399-412.

  50. T. Aprahamian, I. Rifkin, B. Hugel, J.-M. Freyssinet, K. Sato, J.J. Castellot, Jr. and K. Walsh (2004). Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J. Exp. Med. 199: 1121-1131.

  51. J. Magrane, R.C. Smith, K. Walsh and H.W. Querfurth (2004). Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. J. Neurosci. 24: 1700-1706.

  52. H. Kobayashi, N. Ouchi, S. Kihara, K. Walsh, M. Kumada, Y. Abe, T. Funahashi and Y. Matsuzawa (2004). Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ. Res. 94: e27-e31.

  53. I. Shiraishi, J. Melendez, Y. Ahn, M. Skavdahl, E. Murphy, S. Welch, E. Schaefer, K. Walsh, A. Rosenzweig, D. Torella, D. Nurzynska, J. Kajstura, A. Leri, P. Anversa and M.A. Sussman (2004). Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ. Res. 94: 884-891.

  54. D. Torella, M. Rota, D. Nurzynska, E. Musso, A. Monsen, I. Shiraishi, E. Zias, K. Walsh, A. Rosenzweig, M.A. Sussman, K. Urbanek, B. Nadal-Ginard, J. Kajstura, P. Anversa and A. Leri. (2004). Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. 94: 514-524.

  55. M.R. Abid, S. Guo, T. Minami, K.C. Spokes, K. Ueki, C. Skurk, K. Walsh and W.C. Aird (2004). Vascular endothelial growth factor activates PI3K-Akt-Forkhead signaling pathway in endothelial cells. Arterioscler.Thromb. Vasc. Biol. 24: 294-300.

  56. N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, T. Inoue, T. Funahashi and K. Walsh (2004). Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279: 1304-1309.

  57. C. Skurk, H. Maatz, H.S. Kim, J. Yang, M.R. Abid, W.C. Aird and K. Walsh (2004). The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J. Biol. Chem. 279: 1513-1525.

  58. H.J. Cho, H.S. Kim, M.M. Lee, D.H. Kim, H.J. Yang, J. Hur, K.K. Hwang, S. Oh, Y.J. Choi, I.H. Chae, B.H. Oh, Y.S. Choi, K. Walsh and Y.B. Park (2003). Mobilized endothelial progenitor cells by granulocyte-macrophage colony-stimulating factor accelerate reendothelialization and reduce vascular inflammation after intravascular radiation. Circulation 108: 2918-2925.

  59. H. Perlman, N. Nguyen, H. Liu, J. Eslick, S. Esser, K. Walsh, T.L. Moore and R.M. Pope (2003). Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand R3. Arthritis & Rheumatism 48: 3096-3101.

  60. S. Kovacic, C.L. Soltys, A.J. Barr, I. Shiojima, K. Walsh and J.R. Dyck (2003). Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J. Biol. Chem. 278: 39422-39427.

  61. M. Mogi, J. Yang, J.F. Lambert, G.A. Colvin, I. Shiojima, C. Skurk, R. Summer, A. Fine, P.J. Quesenberry and K. Walsh (2003). Akt signaling regulates side population cell phenotype via Bcrp1 translocation. J. Biol. Chem. 278: 39068-39075.

  62. K.W. Park, H.M. Yang, S.W. Youn, H.J. Yang, I.H. Chae, B.H. Oh, M.M. Lee, Y.B. Park, Y.S. Choi, H.S. Kim and K. Walsh (2003). Constitutively active glycogen synthase kinase-3{beta} gene transfer sustains apoptosis, inhibits proliferation of vascular smooth muscle cells, and reduces neointima formation after balloon injury in rats. Arterioscler. Thromb. Vasc. Biol. 23: 1364-1369.

  63. D. Nagata, M. Mogi and K. Walsh (2003). AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J. Biol. Chem. 278: 31000-31006.

  64. A. Takahashi, M. Palmer-Opolski, R.C. Smith and K. Walsh (2003). Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent. Gene Ther. 10: 1471-1478.

  65. J. Yang, S.P. Jones, T. Suhara, J.J.M. Greer, P.D. Ware, N.P. Nguyen, H. Perlman, D.P. Nelson, D.J. Lefer and K. Walsh (2003). Endothelial cell overexpression of Fas ligand attenuates ischemia-reperfusion injury in the heart. J. Biol. Chem. 278: 15185-15191.

  66. A.C. Lake, A. Bialik, K. Walsh and J.J. Castellot Jr. (2003). CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility. Am. J. Pathol. 162: 219-231.

  67. A. Skaletz-Rorowski, M. Lutchman, Y. Kureishi, D.J. Lefer, J.R. Faust and K. Walsh (2003). HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells. Cardiovasc. Res. 57: 253-254.

  68. H. Perlman, K. Bradley, H. Liu, S. Cole, E. Shamiyeh, R.C. Smith, K. Walsh, S. Fiore, A.E. Koch, G.S. Firestein, G.K. Haines and R.M. Pope (2003). IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts. J. Immunol. 170: 838-845.

  69. P. Lee, M. Sata, D.J. Lefer, S.M. Factor, K. Walsh and R.N. Kitsis (2003). The Fas pathway is a critical mediator of cardiac myocyte death and myocardial infarction during ischemia/reperfusion in vivo. Am. J. Physiol. Heart Circ. Physiol. 284: H456-H463.

  70. T. Suhara, J. Magrané, K. Rosen, R. Christensen, H.S. Kim, B Zheng, D.L. McPhie, K. Walsh and H. Querfurth (2003). Aβ42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3β signaling-dependent mechanism. Neurobiol. Aging 24: 437-451.

  71. E. Schonherr, B. Levkau, L. Schaefer, H. Kresse and K. Walsh (2002). Decorin affects endothelial cells by Akt-dependent and -independent pathways. Ann. N.Y. Acad. Sci. 973: 149-152.

  72. I. Six, Y. Kureishi, Z. Luo and K. Walsh (2002). Akt signaling mediates VEGF/VPF vascular permeability in vivo. FEBS Lett. 532: 67-69.

  73. C. Furman, Z. Luo, K. Walsh, N. Duverger, C. Coplin, J.C. Fruchart and M. Ruiz (2002). Systemic tissue inhibitor metalloproteinase-1 gene delivery reduces intimal hyperplasia in balloon-injured rat carotid artery. FEBS Lett. 31: 122-126.

  74. H.S. Kim, C. Skurk, S.R. Thomas, A. Bialik, Y. Kureishi, M. Birnbaum, J.F. Keaney and K. Walsh (2002). Regulation of angiogenesis by glycogen synthase kinase-3beta signaling in endothelial cells. J. Biol. Chem. 277: 41888-41896.

  75. I. Shiojima, M. Yefremashvili, Z. Luo, Y. Kureishi, A. Takahashi, J. Tao, A. Rosenzweig, C.R. Kahn, E.D. Abel and K. Walsh (2002). Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J. Biol. Chem. 277: 37670-37677.

  76. M.H. Zou, X.Y. Hou, C.M, Shi, D. Nagata, K. Walsh, R.A. Cohen (2002). Modulation by Peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J. Biol. Chem. 277: 32552-32557.

  77. M. Sata, A. Takahashi, K. Tanaka, M. Washida, N. Ishizaka, J. Ako, M. Yoshizumi, Y. Ouchi, T. Taniguchi, Y. Hirata, M. Yokoyama, R. Nagai and K. Walsh (2002). Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway. Arterioscler. Thromb. Vasc. Biol. 22: 1305-1309.

  78. Y. Taniyama and K. Walsh (2002). Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth. J. Mol. Cell. Cardiol. 34: 1241-1247.

  79. E. Suzuki, H. Nishimatsu, H. Satonaka, K. Walsh, A. Goto, M. Omata, T. Fujita, R. Nagai and Y. Hirata (2002). Angiotensin II induces myocyte enhancer factor 2- and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes. Circ. Res. 90: 1004-1011.

  80. R.C. Smith, M. Machluf, P. Bromley, A. Atala and K. Walsh (2002). Spatial and temporal control of transgene expression through ultrasound-mediated induction of the Heat Shock Protein 70B promoter in vivo. Hum. Gene Ther. 6: 697-706.

  81. A. Takahashi, Y. Kureishi, J. Yang, Z. Luo, K. Guo, D. Mukhopadhyay, Y. Ivashchenko, D. Branellec and K. Walsh (2002). Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth. Mol. Cell. Biol. 22: 4803-4814.

  82. C.-L.M. Soltys, L. Buchholz, M. Gandhi, A.S. Clanachan, K. Walsh and J.R.B. Dyck (2002). Phosphorylation of Cardiac Protein Kinase B is regulated by Palmitate. Am. J. Physiol. 283: H1056-H1064.

  83. Z.H. Lee, S.E. Lee, C.W. Kim, S.H. Lee, S.W. Kim. K. Kwack, K Walsh and H.H. Lee (2002). IL-1a stimulation of osteoclast survival through the PI 3-kinase/Akt and ERK pathways. J. Biochem. 131: 161-166.

  84. H. Perlman, H. Liu, C. Georganas, J.M. Woods, M.A. Amin, A.E. Koch. I. Kovesdi T. Mano, K. Walsh and R.M. Pope (2002). Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression. J. Rheumatol. 29: 1593-1600.

  85. Y.C. Boo, G. Sorescu, N. Boyd, I. Shiojima, K Walsh, J. Du, K. Walsh and H. Jo (2002). Shear stress stimulates eNOS phosphorylation at Ser 1179 by Akt-independent mechanisms – Role of Protein Kinase A. J. Biol. Chem. 277: 3388-3396.

  86. T. Suhara, L.A. Kirshenbaum and K. Walsh (2002). Suppression of Akt signaling induces Fas ligand expression: The involvement of caspase and c-Jun kinase activation in Akt-mediated Fas ligand regulation. Mol. Cell. Biol. 22: 680-691.

  87. K.N. Wills, T. Mano, J.B. Avanzini, T. Nguyen, D. Antelman, R.J. Gregory, R.C. Smith and K Walsh (2001). Tissue-specific expression of an anti-proliferative hybrid transgene from the human smooth muscle alpha-actin promoter suppresses smooth muscle cell proliferation and neointima formation. Gene Ther. 8: 1847-1854.

  88. I. Kim, J. Oh, Y. Ryn, J. So, WC Sessa, K Walsh and G. Koh (2001). Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells. FASEB J. 16: 126-128.

  89. E. Schonherr, B. Levkau, L. Schaefer, H. Kresse and K. Walsh (2001). Decorin-mediated signal transduction in endothelial cells: Involvement of the Akt/protein kinase B in up-regulation of p21WAF1/CIP1 but not p27KIP1. J. Biol. Chem. 276: 40687-40692.

  90. S. Blum, K. Ißbrucker, A. Willuweit, S. Hehlgans, M. Lucerna, D. Mechtcheriakova, K. Walsh, D. von Der Ahe, E. Hofer, and M. Clauss. (2001). An inhibitory role of the phosphatidylinositol 3-kinase signaling pathway in vascular endothelial growth factor-induced tissue factor expression. J. Biol. Chem. 276: 33428-33434.

  91. Y. Fujio, Y. Mitsuuchi, J.R. Testa and K Walsh (2001). Activation of Akt2 inhibits anoikis and apoptosis induced by myogenic differentiation. Cell Death Diff. 8: 1207-1212.

  92. Y. M. Go, Y.C. Boo, H. Park, M.C. Meland, R. Patel, K.A. Pritchard, Y. Fujio, K. Walsh, V. Darley-Usmar and H. Jo (2001). Protein Kinase B/Akt activates c-Jun N-terminal kinase by increasing nitric oxide production in response to shear stress. J. Applied Physiol. 91: 1574-1581.

  93. J. Llevadot, S. Murasawa, Y. Kureishi, S. Uchida, H. Masuda, A. Kawamoto, K. Walsh, J.M. Isner, and T. Asahara (2001). HMG-CoA reductase inhibitor mobilizes bone-marrow derived endothelial progenitor cells. J. Clin. Invest. 108: 399-405.

  94. J.P.Gratton, M. Morales-Ruiz, Y. Kureishi, D. Fulton, K. Walsh and W.C. Sessa (2001). Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J. Biol. Chem. 276: 30359-30365.

  95. T. Suhara, T. Mano, B.E. Oliveira and K. Walsh (2001). Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP). Circ. Res. 89: 13-19.

  96. H. Nishimatsu, E. Suzuki, D. Nagata, N. Moriyama, H. Satonaka, K. Walsh, M. Sata, K. Kangawa, H. Matsuo, A. Goto, T. Kitamura, and Y. Hirata. (2001). Adrenomedullin induces endothelium-dependent vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-dependent pathway in rat aorta. Circ. Res. 89: 63-70.

  97. M. Sata, Z. Luo and K. Walsh (2001). Fas ligand overexpression on allograft endothelium inhibits inflammatory cell infiltration and transplant-associated intimal hyperplasia. J. Immunol. 166: 6964-6971.

  98. M. Morales-Ruiz, M-J. Lee, S. Zollner, J.P. Gratton, R. Scotland, I. Shiojima, K. Walsh, T. Hla and W.C. Sessa (2001). Sphingosine-1-phosphate activates Akt, nitric oxide production and chemotaxis through a Gi-protein/ phosphoinositide 3-kinase pathway in endothelial cells. J. Biol. Chem. 276: 19672-19677.

  99. M. Zhang, D. Methot, V. Poppa, Y. Fujio, K. Walsh and C.E. Murry (2001). Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies. J. Mol. Cell. Cardiol. 33: 907-921.

  100. H. W. Querfurth, T. Suhara, K. M. Rosen, D.L. McPhie, Y. Fujio, G. Tejada, R.L. Neve, L.S. Adelman and K. Walsh (2001). β-amyloid peptide expression is sufficient for myotube death: Implications for human inclusion body myopathy. Mol. Cell. Neurosci. 17: 793-810.

  101. S. Negoro, H. Oh, E. Tone, K. Kunisada, Y. Fujio, K Walsh, T. Kishimoto and K. Yamauchi-Takihara (2001). Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction. Circulation 103: 555-561.

  102. D.J. Panka, T. Mano, T. Suhara, K. Walsh and J.W. Mier (2001). Phosphatidylinositol-3 kinase/Akt regulates c-FLIP expression in tumor cells. J. Biol. Chem. 276: 6893-6896.

  103. Y. Lu, L. Parkyn, L. Otterbein, Y. Kureishi, K. Walsh, A. Ray, and P. Ray (2001). Activated Akt protects the lung from oxidant-induced injury and delays death of mice. J. Exp. Med. 193: 545-549.

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  104. W. Miao, Z. Luo, R.N. Kitsis and K. Walsh (2000). Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. J. Mol. Cell. Cardiol. 32: 2397-2402.

  105. D. Nagata, E. Suzuki, H. Nishumatsu, M. Yoshizumi, T. Mano, K Walsh, M. Sata, M. Kakoki, A. Goto, M. Omata and Y. Hirata (2000). Cyclin A downregulation and p21cip1 upregulation correlate with GATA-6-Induced growth arrest in glomerular mesangial cells. Circ. Res. 87: 699-704.

  106. M. L. Hixon, C. Muro-Cacho, M.W. Wagner, C. Obejero-Paz, E. Millie, Y. Fujio, Y. Kureishi, T. Hassold, K. Walsh and A. Gualberto (2000). Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization. J. Clin. Invest. 106: 1011-1020.

  107. M. Funamoto, Y. Fujio, K. Kunisada, S. Negoro, E. Tone, T. Osugi, H. Hirota, M. Izumi, K. Yoshizaki, K. Walsh, T. Kishimoto, K. Yamauchi-Takihara (2000). Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes. J Biol. Chem. 275: 10561-10566.

  108. Y. Kureishi, Z. Luo, I. Shiojima, A. Bialik, D. Fulton, D.J. Lefer, W.C. Sessa and K. Walsh (2000). The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat. Med. 6: 1004-1010.

  109. Z. Luo, Y. Fujio, Y. Kureishi, R.D. Rudic, G. Daumerie, D. Fulton, W.C. Sessa and K. Walsh (2000) Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J. Clin. Invest. 106: 493-499.

  110. L. Maillard, E. Van Belle, F.O. Tio, A. Rivard, M. Kearney, D. Branellec, P.G. Steg, J.M. Isner, and K. Walsh (2000). Percutaneous local delivery of adenovirus-mediated GAX gene to the arterial wall inhibits restenosis in atheromatous stented rabbit iliac arteries. Gene Ther. 7: 1353-1361.

  111. T. Mano, Z. Luo, T. Suhara, R.C. Smith, S. Esser and K. Walsh (2000). Expression of wild-type and non-cleavable Fas ligand by tetracycline-regulated adenoviral vectors to limit intimal hyperplasia in vascular lesions. Hum. Gene Ther. 11: 1625-1635.

  112. M. Sata and K. Walsh (2000). Fas ligand-deficient mice display enhanced leukocyte infiltration and intima hyperplasia in flow restricted vessels. J. Mol. Cell. Cardiol. 32: 1395-1400.

  113. M. Morales-Ruiz, D. Fulton, G. Sowa, L.R. Languino, Y. Fujio, K. Walsh, and W.C. Sessa (2000). Vascular endothelial growth factor stimulated actin reorganization and migration of endothelial cells is regulated via the Akt/nitric oxide synthase pathway. Circ. Res. 86: 892-896.

  114. M. Palasis, Z. Luo, J.J. Barry and K. Walsh (2000). Analysis of adenoviral transport mechanisms in the vessel wall and optimization of gene transfer using local delivery devices. Hum. Gene Ther. 11: 237-246.

  115. D. Chen, K. Walsh and J. Wang (2000). Regulation of cdk2 activity in endothelial cells that are inhibited from growth by cell contact. Atheroscl. Thromb. Vasc. Biol. 20: 629-635.

  116. Y. Fujio, T. Nguyen, D. Wencker, R.N. Kitsis and K. Walsh (2000). Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667.

  117. H. Perlman, M. Sata, K. Krasinski, T. Dorai, R. Buttyan and K. Walsh (2000). Adenovirus-encoded hammerhead ribozyme to Bcl-2 inhibits neointimal hyperplasia and induces smooth muscle cell apoptosis. Cardiovasc. Res. 45: 570-578.

  118. M. Sata, T. Suhara and K. Walsh (2000). Vascular endothelial cells and smooth muscle cells differ in their expression of Fas and Fas ligand and in their sensitivity to Fas ligand-induced cell death: Implications for vascular disease and therapy. Atheroscl. Thromb. Vasc. Biol. 20: 309-316.

  119. H. Perlman, L.J. Pagliari, C. Georganas, T. Mano, K. Walsh and R.M. Pope (1999). FLICE-inhibitory protein expression during macrophage differentiation confers resistance to Fas-mediated apoptosis. J. Exp. Med. 190: 1679-1688.

  120. B. Witzenbichler, Y. Kureishi, Z. Luo, A. Le Roux, D. Branellec and K. Walsh (1999). Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor. J. Clin. Invest. 104: 1469-1480.

  121. C. Broceno, K. Walsh and G. Pons (1999). A 1.3-kb upstream 5' region of the rat phosphoglycerate mutase m gene confers testis and skeletal muscle-specific expression in transgenic mice. Biochem. Biophys. Res. Commun. 263: 244-250.

  122. M. Ushio-Fukai, R.W. Alexander, M. Akers, Q.Q. Yin, Y. Fujio, K. Walsh, K.K. Griendling (1999). Reactive oxygen species mediate activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 274: 22699-22704.

  123. M. Sata and K. Walsh (1999). Cyclosporin downregulates Fas ligand expression on vascular endothelial cells: Implications for accelerated vasculopathy by immunosuppressive therapy. Biochem. Biophys. Res. Commun. 263: 430-432.

  124. T. Dorai, H. Perlman, K. Walsh, A. Shabsigh, E.T. Goluboff, C.A. Olsson and R. Buttyan (1999). A recombinant defective adenovirus agent expressing anti-Bcl-2 ribozyme promotes apoptosis of Bcl-2 expressing human prostate cancer cells. Int. J. Cancer. 82: 846-852.

  125. D. Fulton, J.P. Gratton, T. McCabe, J. Fontana, Y. Fujio, K. Walsh, T. Franke, A. Papapetropoulos, W.C. Sessa (1999). Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601.

  126. Y. Fujio, K. Guo, T. Mano, Y. Mitsuuchi, J.R. Testa and K. Walsh (1999). Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol. Cell. Biol. 19: 5073-5082.

  127. Y. Fujio and K. Walsh (1999). Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J. Biol. Chem. 274: 16349-16354.

  128. H. Perlman, Z. Luo, A. Le Roux, A. Mahfoudi, R. C. Smith, D. Branellec, K. Walsh (1999). Adenoviral-mediated delivery of the Gax transcription factor to rat carotid arteries inhibits smooth muscle proliferation and induces apoptosis. Gene Ther. 6: 758-763.

  129. T. Mano, Z. Luo, S.L. Malendowicz, T. Evans and K. Walsh (1999). Reversal of GATA-6 downregulation promotes smooth muscle differentiation and inhibits intimal hyperplasia in balloon-injured rat carotid artery. Circ. Res. 84: 647-654.

  130. Z. Luo, M. Sata, T. Nguyen, J.M. Kaplan, G.Y. Akita and K. Walsh (1999). Adenovirus-mediated delivery of Fas ligand inhibits intimal hyperplasia following balloon injury in immunologically-primed animals. Circulation 99: 1776-1779.

  131. Z.F. Cheema, S.B. Wade, M. Sata, K. Walsh, F. Sohrabji, R.C. Miranda (1999). Fas/Apo [Apoptosis]-1 and associated proteins in the differentiating cerebral cortex: Induction of caspase-dependent cell death and activation of NF-κB. J. Neurosci. 19: 1754-1770.

  132. A. Rivard, Z. Luo, H. Perlman, J.E. Fabre, T. Nguyen, L. Maillard and K. Walsh (1999). Early cell loss following angioplasty results in a disproportionate decrease in percutaneous gene transfer to the vessel wall. Hum. Gene Ther. 10: 711-721.

  133. H. Perlman, X. Zhang, M.W. Chen, K. Walsh and R. Buttyan (1999). Differential expression of bax and bcl-2 gene products in rat ventral prostate gland after castration: an elevated bax/bcl-2 ratio corresponds with the onset of apoptosis in regressing prostate gland. Cell Death Diff. 6: 48-54.

  134. M. Sata and K. Walsh (1998). Endothelial cell apoptosis induced by oxidized LDL is associated with the downregulation of the cellular caspase inhibitor FLIP. J. Biol. Chem. 273: 33103-33106.

  135. M. Sata and K. Walsh (1998). Oxidized LDL activates Fas-mediated endothelial cell apoptosis. J. Clin. Invest. 102: 1682-1689.

  136. Z. Luo, K. G. Shyu, A. Gualberto and K. Walsh (1998). Calcineurin and pressure overload-induced cardiac hypertrophy. Nat. Med. 4: 1092-1093.

  137. H. Perlman, M. Sata, A. Le Roux, T. Sedlak, D. Branellec, and K. Walsh (1998). Bax-mediated cell death by the Gax homeoprotein requires mitogen-activation but is independent of cell cycle activity. EMBO J. 17: 3576-3586.

  138. H. Perlman, E. Suzuki, M. Simonson, R. Smith and K. Walsh (1998). GATA-6 induces p21CIP1 expression and G1 cell cycle arrest. J. Biol. Chem. 273: 13713-13718.

  139. E. Van Belle, L. Maillard, A. Rivard, J.E. Fabre, T. Couffinhal, M. Kearney, D. Branellec, L.J. Feldman, K. Walsh and J.M. Isner (1998). Effects of Poloxamer 407 on transfection time and percutaneous adenovirus-mediated gene transfer in native and stented vessels. Hum. Gene Ther. 9: 1013-1024.

  140. M. Sata and K. Walsh (1998). TNFα-regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation. Nat. Med. 4: 415-420.

  141. K. Guo, V. Andrés, and K. Walsh (1998). Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Circulation 97: 2066-2072.

  142. M. Sata, H. Perlman, D.A. Muruve, M. Silver, M. Ikebe, T.A. Libermann, P. Oettgen , and K. Walsh (1998). Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. Proc. Natl. Acad. Sci. USA 95: 1213-1217.

  143. I. Baumgartner, A. Pieczek, O. Manor, R. Blair, M. Kearney, K. Walsh, and J.M. Isner (1998). Constitutive expression of phVEGF165 following intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation. 97: 1114-1123.

  144. S.A. Fisher, E. Siwik, D. Branellec, K. Walsh and M. Watanabe (1997). Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis. Development 124: 405-4413.

  145. L. Maillard, E. Van Belle, R.C. Smith, A. Le Roux, P. Denèfle, G. Steg, J.J. Barry, D. Branellec, J.M. Isner and K. Walsh (1997). Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty. Cardiovasc. Res. 35: 536-546.

  146. R.C. Smith, D. Branellec, D.H. Gorski, K. Guo, H. Perlman J.F. Dedieu, C. Pastore, A. Mahfoudi, P. Denèfle, J.M. Isner and K. Walsh (1997). p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Genes Dev. 11: 1674-1689.

  147. R.C. Smith, K.N. Wills, D. Antelman, H. Perlman, L.N. Truong, K. Krasinski and K. Walsh (1997). Adenoviral constructs encoding phosphorylation-competent full-length and truncated forms of the human retinoblastoma protein inhibit myocyte proliferation and neointima formation. Circulation 96: 1899-1905.

  148. G.L. Wei, K. Krasinski, J.M. Isner, K Walsh and V. Andrés (1997). Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty. Circ. Res. 80: 418-426.

  149. K.A. Martin, A. Gualberto, M.F. Kolman, J. Lowry and K. Walsh (1997). A competitive mechanism of CArG element regulation by YY1 and SRF: implications for assessment of transcription factor interactions at CArG elements. DNA Cell Biol. 16: 653-661.

  150. H.A. Skopicki, G.E. Lyons, G. Schatteman, R.C. Smith, V. Andrés, S. Schirm, J.M. Isner and K. Walsh (1997). Embryonic expression of the gax homeodomain protein in cardiac, smooth and skeletal muscle. Circ. Res. 80: 452-462.

  151. J. Wang, K. Guo, K.N. Wills and K. Walsh (1997). Rb functions to inhibit apoptosis during myocyte differentiation. Cancer Res. 57: 351-354.

  152. H. Perlman, L. Maillard, K. Krasinski and K. Walsh (1997). Evidence for the rapid onset of apoptosis in medial smooth muscle cells following balloon injury. Circulation 95: 981-987.

  153. K. Guo and K. Walsh (1997). Inhibition of myogenesis by multiple cyclin/cdk complexes: Coordinate regulation of myogenesis and cell cycle activity at the level of E2F. J. Biol. Chem. 272: 791-797.

  154. E. Suzuki, T. Evans, J. Lowry, L. Truong, D.W. Bell, J.R. Testa and K. Walsh. (1996). The human GATA-6 gene: Structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals. Genomics 38: 283-290.

  155. J. Wang, K. Walsh (1996). Inhibition of retinoblastoma protein phosphorylation by myogenesis-induced changes in the subunit composition of the cyclin-dependent kinase 4 complex. Cell Growth Diff. 7: 1471-1478.

  156. J.M. Isner, A. Pieczek, R. Schainfeld, R. Blair, L. Haley, T. Asahara, K. Rosenfield, S. Razvi, K. Walsh and J. Symes (1996). Clinical evidence of angiogenesis following arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348: 370-374.

  157. J. Wang and K. Walsh (1996). Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science 273: 359-361.

  158. E. Suzuki, J. Lowry, G. Sonoda, J.R. Testa and K. Walsh (1996). Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP. Cytogenet. Cell Genet. 73: 244-249.

  159. V. Andrés and K. Walsh (1996). Myogenin expression, cell cycle withdrawal and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis. J. Cell Biol. 132: 657-666.

  160. S.A. Fisher, K. Walsh, C.J. Forehand (1996). Characterization of cardiac gene cis-regulatory elements in the early stages of chicken heart morphogenesis. J. Mol. Cell. Cardiol. 28: 113-122.

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  161. D. Altomare, K. Guo, G. Sonoda, J.Q. Cheng, K. Walsh and J.R. Testa (1995). Cloning, nucleotide sequence, chromosomal localization and expression of the mouse Akt2. Oncogene. 11: 1055-1060.

  162. V. Andrés, S. Fisher, P. Wearsch and K. Walsh (1995). Regulation of Gax homeobox gene transcription by a combination of positive factors including Myocyte-Specific Enhancer Factor 2. Mol. Cell Biol. 15: 4272-4281.

  163. K. Guo, J. Wang, V. Andrés, R.C. Smith and K. Walsh (1995). MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Mol. Cell. Biol. 15: 3823-3829.

  164. J.M. Isner, K. Walsh, J. Symes, A. Pieczek, S. Takeshita, J. Lowry, S. Rossow, K. Rosenfield, L. Weir, E. Brogi and R. Schainfeld (1995). Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation 91: 2687-2692.

  165. E. Suzuki, K. Guo, M. Kolman, Y.T. Yu, and K. Walsh (1995). Serum-induction of MEF2/RSRF expression in vascular myocytes is mediated at the level of translation. Mol. Cell. Biol. 15: 3415-3423.

  166. M.S. Simonson, K. Walsh, C.C. Kumar, P. Bushel and W. Herman (1995). Two proximal CArG elements regulate SM α-actin promoter, a genetic marker of the activated phenotype of mesangial cells. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F760-F769.

  167. A. Gualberto, J. Lowry, I.M. Santoro and K. Walsh (1995). Parameters that influence the extent of site occupancy by a candidate telomere end-binding protein. J. Biol. Chem. 270: 4509-4517.

  168. L. Weir, D. Chen, C. Pastore, J.M. Isner and K. Walsh (1995). Expression of GAX, a growth-arrest homeobox gene, is rapidly downregulated in rat carotid artery during the proliferative response to balloon injury. J. Biol. Chem. 270: 5457-5461.

  169. M.S. Simonson, D.F. LePage and K. Walsh (1995). Rapid characterization of growth arrest genes in transient transfection assays. BioTechniques 18: 434-442.

  170. D.F. LePage, D.A. Altomare, J.R. Testa and K. Walsh (1994). Molecular cloning and localization of the human GAX gene to 7p21. Genomics 24: 535-540.

  171. P. Ruiz-Lozanol, L. de Lecea, C. Buesa, P. Perez de la Ossal, D. LePage, A. Gualberto, K. Walsh and G. Pons (1994). The gene encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells. Gene 147: 243-248.

  172. K.A. Martin, K. Walsh and S.L. Mader (1994). Paired E-box elements confer muscle-specific expression to a heterologous promoter. Gene 142: 275-278.

  173. D.H. Gorski, D.F. LePage and K. Walsh (1994). Cloning and sequence analysis of homeobox transcription factor cDNAs with and inosine-containing probe. Biotechniques 16: 856-865.

  174. K. Walsh (1993). MyoD and c-fos expression. Nature 365: 611-612.

  175. D.H. Gorski, D.F. LePage, C.V. Patel, N.G. Copeland, N.A. Jenkins and K. Walsh (1993). Molecular cloning of a divergent homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells. Mol. Cell. Biol. 13: 3722-3733.

  176. C.K. Vincent, A. Gualberto, C.V. Patel and K. Walsh (1993). Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle. Mol. Cell. Biol. 13: 1264-1272.

  177. C.V. Patel, D.H. Gorski, D.F. LePage and K. Walsh (1992). Molecular cloning of a homeobox transcription factor from adult aortic smooth muscle. J. Biol. Chem. 267: 26085-26090.

  178. A. Gualberto, D. LePage, G. Pons, R.M. Patrick, S.L. Mader, K. Park, M.L. Atchison and K. Walsh (1992). Functional antagonism between YY1 and the serum response factor. Mol. Cell. Biol. 12: 4209-4214.

  179. K. Walsh and A. Gualberto (1992). MyoD binds to the guanine tetrad nucleic acid structure. J. Biol. Chem. 267: 13714-13718.

  180. A. Gualberto, R.M. Patrick and K. Walsh (1992). Nucleic acid specificity of a vertebrate telomere-binding protein: Evidence for G·G base pair recognition at the core binding site. Genes Dev. 6: 815-824.

  181. I.M. Santoro and K. Walsh (1991). Natural and synthetic CArG elements differ in expression and protein-binding properties. Mol. Cell. Biol. 11: 6296-6305.

  182. T.M. Yi, K. Walsh and P. Schimmel (1991). Rabbit muscle creatine kinase: Genomic cloning, sequencing, and analysis of upstream sequences important for expression in myocytes. Nucl. Acids Res. 19: 3027-3033.

  183. H. Ernst, K. Walsh, C.A. Harrison and N. Rosenthal (1991). A fragment of the MLC1/3 enhancer contains a binding site for the skeletal actin promoter factors MAPF1 and MAPF2 and can function as an orientation-dependent promoter element. Mol. Cell. Biol. 11: 3735-3744.

  184. I.M. Santoro, T.M. Yi and K. Walsh (1991). Identification of single-stranded DNA-binding activities that interact with muscle gene elements. Mol. Cell. Biol. 11: 1944-1953.

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  185. K. Walsh (1989). Cross-binding of nuclear factors to functionally different promoter elements in the c-fos and skeletal actin genes. Mol. Cell. Biol. 9: 2191-2201.

  186. K. Walsh and P. Schimmel (1988). DNA binding site for two skeletal actin promoter factors is important for expression in muscle cells. Mol. Cell. Biol. 8: 1800-1802.

  187. K. Walsh and P. Schimmel (1987) Two nuclear factors compete for the skeletal muscle actin promoter. J. Biol. Chem. 262: 9429-9432.

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  188. K. Walsh and D.E. Koshland, Jr. (1985). Characterization of rate-controlling steps in vivo using an adjustable expression vector. Proc. Natl. Acad. Sci. USA 82: 3577-3581.

  189. K. Walsh and D.E. Koshland, Jr. (1985). Branch point control by the phosphorylation state of isocitrate dehydrogenase. A quantitative examination of fluxes during a regulatory transition. J. Biol. Chem. 260: 8430-8437.

  190. D.C. LaPorte, K. Walsh and D.E. Koshland, Jr. (1984). The branch point effect: Ultrasensitivity and subsensitivity to metabolic control. J. Biol. Chem. 259: 14068-14075.

  191. K. Walsh and D.E. Koshland, Jr. (1984). Determination of flux through the branch point of two metabolic cycles. The tricarboxylic acid cycle and the glyoxylate shunt. J. Biol. Chem. 259: 9646-9654.

  192. A. Dafforn, J.P. Neenan, C.P. Ash, L. Betts, J.M. Finke, M. Garman, M. Rao, K. Walsh, and R.R. Williams. (1982). Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and 1-halo-3-phenoxy-2propanones. Biochem. Biophys. Res. Commun. 104: 597-602.

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  193. K. Walsh, D.M. Millikin, K.K. Schlender and E.M. Reimann (1980). Stimulation of phosphorylase b kinase by the calcium-dependent regulator. J. Biol. Chem. 255: 5036-5042.

  194. K. Walsh, D.M. Millikin, K.K. Schlender and E.M. Reimann (1979). Calcium-dependent phosphorylation of glycogen synthase by phosphorylase kinase. J. Biol. Chem. 254: 6611-6616.

  195. J.M. Isner, K. Walsh, J. Symes, A. Pieczek, S. Takeshita, J. Lowry, K. Rosenfield, L. Weir, E. Brogi, D. Jurayj (1996). Clinical protocol: Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery disease. Hum. Gene Ther. 7: 959-988.

  196. J.M. Isner, K. Walsh, K. Rosenfield, R. Schainfeld, T. Asahara, K. Hogan, A. Pieczek (1996). Clinical protocol: Arterial gene therapy for restenosis. Hum. Gene Ther. 7: 989-1011.

  197. K. Walsh and P. Schimmel (1988). Preliminary characterization of muscle actin promoter factors 1 and 2 and their interaction with the skeletal actin promoter. Mol. Cell. Biol. New Ser. 93: 669-676.

  198. K. Walsh, M. Schena, A.J. Flint and D.E. Koshland (1986). Compensatory regulation in metabolic pathways - responses to increases and decreases in citrate synthase levels. Biochem. Soc. Symp. 54: 183-195.

  199. KN. Papanicolaou, Y. Izumiya, K. Walsh (2007). Forkhead transcription factors and cardiovascular biology. Circ. Res. In press.

  200. Y. Takemura, K. Walsh, N. Ouchi (2007). Adiponectin and cardiovascular inflammatory responses. Curr Atheroscler Rep. In press.

  201. K. Walsh, I. Shiojima (2007). Cardiac growth and angiogenesis coordinated by intertissue interactions. J. Clin. Invest. 117 :3176-3179.

  202. N. Ouchi, R. Shibata, K. Walsh (2007). Cardioprotective actions of adiponectin. High Blood Press Cardiovasc Prev. 14 :69-73.

  203. N. Ouchi and K. Walsh (2007). Adiponectin as an anti-inflammatory factor. Clin. Chim. Acta. In press.

  204. TA. Hopkins,N. Ouchi, R. Shibata, K. Walsh (2006). Adiponectin actions in the cardiovascular system. Cardiovasc Res [Epub ahead of print]

  205. N. Ouchi, R. Shibata, K. Walsh (2006). Targeting adiponectin for cardioprotection. Expert Opin Ther Targets 10: 573-581.

  206. N. Ouchi, R. Shibata, K. Walsh (2006). Cardioprotection by adiponectin. Trends Cardiovasc Med 16: 141-146.

  207. I. Shiojima and K. Walsh (2005) Regulation of angiogenesis and vascular remodeling by endothelial Akt signaling. In The Endothelium: A Comprehensive Reference. William Aird Editor. Cambridge University Press.

  208. A. Skaletz-Rorowski, Y. Kureishi, I. Shiojima and K. Walsh (2004). The pro- and antiangiogenic effects of statins. Seminars in Vascular Medicine 4: 395-400.

  209. I. Shiojima, K. Walsh (2004). The role of vascular endothelial growth factor in restenosis: the controversy continues. Circulation 110: 2283-2286.

  210. C. Skurk and K Walsh (2004). Death receptor induced apoptosis. A new mechanism of homocysteine-mediated endothelial cell cytotoxicity. Hypertension 43: 1168-1170.

  211. D.H. Gorski and K. Walsh (2003). Control of vascular cell differentiation by homeobox transcription factors. Trends Cardiovasc Med. 13: 213-220.

  212. A. Skaletz-Rorowski and K. Walsh (2003). Statin therapy and angiogenesis. Curr. Opin. Lipid. 14: 599-603.

  213. N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa and K. Walsh (2003). Obesity, adiponectin and vascular inflammatory disease. Curr. Opin. Lipid. 14: 561-566.

  214. I. Shiojima and K. Walsh (2002). Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 90: 1243-1250.

  215. R.C. Smith and K. Walsh (2001). Local gene delivery to the vessel wall. Acta Physiol. Scand. 173: 93-102.

  216. K. Walsh and A. Takahashi (2001). Transcriptional regulation of vascular smooth muscle cell phenotype. Z. Kardiol. 90 (Suppl 3): 12-16.

  217. D.H. Gorski and K. Walsh (2001). Control of vascular cell differentiation by homeobox transcription factors. Circ. Res. 88: 7-8.

  218. D.H. Gorski and K. Walsh (2000). The role of homeobox genes in vascular remodeling and angiogenesis. Circ. Res. 87: 865-872.

  219. K. Walsh (2000). Building a better mouse model. J. Mol. Cell. Cardiol. 32: 1921-1922.

  220. K. Walsh, R.C. Smith and H.S. Kim (2000). Vascular cell apoptosis in remodeling restenosis and plaque rupture. Circ. Res. 87: 184-188.

  221. R.C. Smith and K. Walsh (2000). Gene therapy for restenosis. Curr. Cardiol. Rpts. 2: 13-23.

  222. K. Walsh and J.M. Isner (2000). Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall. Cardiovasc. Res. 45: 756-765.

  223. R.C. Smith, T. Mano and K. Walsh (2000). Transcription factors controlling cellular proliferation during vascular repair. In E.K. Weir, S.L. Archer and J.T. Reeves eds. The fetal and neonatal pulmonary circulations. Futura Publishing Company, New York, NY. 137-147.

  224. K. Walsh, I. Shiojima and A. Gualberto (1999). Commentary: DNA replication and smooth muscle cell hypertrophy. J. Clin. Invest. 104: 673-674.

  225. C. Amant, L. Berthou and K. Walsh (1999). Angiogenesis and gene therapy in humans: hope or reality. Drugs 58: 37-41.

  226. K. Walsh and M. Sata (1999). Regulation of inflammation by Fas ligand expression on the vascular endothelium. In M. Sanders and J. Kostis eds. Molecular Cardiology in Clinical Practice. Kluwer Academic Publishing, Norwell, MA. 125-141.

  227. K. Walsh and M. Sata (1999). Negative regulation of inflammation by Fas ligand expression on the vascular endothelium. Trends Cardiovasc. Med. 9: 34-41.

  228. K. Walsh and M. Sata (1999). Is extravasation a Fas-regulated process? Mol. Med. Today. 5: 61-67.

  229. R. Tio, J.M. Isner and K. Walsh (1998). Gene therapy for restenosis, the Boston experience. Sem. Intervent. Cardiol. 3: 205-210.

  230. A. Le Roux, L. Maillard, V. Conard, N. Ratet, H. Perlman, A. Mahfoudi, J.M. Isner, K. Walsh, D. Branellec (1998). Gene therapy of vascular disorders. Use of gax gene transfer as a molecular strategy to prevent postangioplasty restenosis. In B. Jacot, D. Mathé, J-C. Fruchart eds. Atherosclerosis XI. Elsevier Science Press, St. Louis, MO. 673-683.

  231. K. Walsh, H. Perlman and R.C. Smith (1998). Regulation of vascular smooth muscle differentiation and cell cycle. In N. Rosenthal and R. Harvey eds. Heart Development. Academic Press, San Diego, CA. 429-443.

  232. K. Walsh and H. Perlman (1997). Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Devel. 7: 597-602.

  233. K. Walsh (1997). Coordinate regulation of cell cycle and apoptosis during myogenesis. Prog. Cell Cycle Res. 3: 53-58.

  234. R.C. Smith and K. Walsh (1997). Prospects for intravascular gene therapy. J. Clin. Apheresis. 12: 140-145.

  235. K. Walsh and H.A. Skopicki (1997). Regulation of cell cycle in myocytes that terminally differentiate. In R.L. Kao and R.C-J. Chiu eds. Cellular cardiomyoplasty: Myocardial repair with cell implantation. Landes Biosciences, Austin, TX and Chapman & Hall, New York, NY. 27-43.

  236. K. Walsh and H. Perlman (1996). Molecular strategies to inhibit restenosis: Modulation of the vascular myocyte phenotype. Sem. Intervent. Cardiol. 1: 173-179.

  237. L. Maillard and K. Walsh (1996). Growth-arrest homeobox gene gax : a molecular strategy to prevent arterial restenosis. Schweiz. Med. Wochenschr. 126: 1721-1726.

  238. K. Walsh, K. Guo, J. Wang and V. Andrés (1996). p21 Regulation and function during myogenesis. Mol. Cell. Differ. 4: 17-31.

  239. D.H. Gorski and K. Walsh (1995). Mitogen-responsive nuclear factors that mediate growth control signals in vascular myocytes. Cardiovasc. Res. 30: 585-592.

  240. D.H. Gorski. C.V. Patel and K Walsh (1993). Homeobox transcription factor regulation in the cardiovascular system. Trends Cardiovasc. Med. 3: 184-190.

  241. D.E. Koshland, Jr., K. Walsh and D.C. LaPorte (1985). Sensitivity of metabolic fluxes to covalent control. Curr. Top. Cell. Reg. 27: 13-22.

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